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Anti Mouse Notch 4 Antibody, clone HMN4-14

Hamster Anti-Mouse Monoclonal Antibody

  • FC - Anti Mouse Notch 4 Antibody, clone HMN4-14  ABD12725
    Notch 4 transfected cells stained with Hamster anti Mouse Notch 4 following cell permeabilisation with Leucoperm®
  • FC - Anti Mouse Notch 4 Antibody, clone HMN4-14  ABD12725
    Notch 4 transfected cells stained with Hamster anti Mouse Notch 4:RPE following cell permeabilisation with Leucoperm®
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31695
Reactivity Mouse
Host Hamster
Clonality Monoclonal
Isotype IgG
Clone Names HMN4-14
Calculated MW 206693 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Mouse Notch 4-Fc fusion protein.
Shelf Life 18 months from date of despatch.
Gene ID 18132
Other Names Neurogenic locus notch homolog protein 4, Notch 4, Transforming protein Int-3, Notch 4 extracellular truncation, Notch 4 intracellular domain, Notch4, Int-3, Int3
Target/Specificity Hamster anti Mouse Notch 4 antibody, clone HMN4-14 specifically recognizes mouse Notch 4, one of the four major transmembrane receptors (Notch 1-4) of the Notch signaling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Notch 4 is expressed by endothelial cells, macrophages, and CD8+ splenic dendritic cells, and Notch 4 signaling may play a crucial role in vasculogenesis and angiogenesis. In mice, a truncated constitutively active form of Notch 4, designated Int3, also exists, as a result of the mouse mammary tumor virus (MMTV).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Mouse Notch 4 Antibody, clone HMN4-14 is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD12725
(40 western blots)
Availability: Inquire
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