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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti Mouse Delta-Like Protein 1 Antibody, clone HMD1-5    

Anti Mouse Delta-Like Protein 1 Antibody, clone HMD1-5

Hamster Anti-Mouse Monoclonal Antibody

  • IHC-P - Anti Mouse Delta-Like Protein 1 Antibody, clone HMD1-5  ABD12726
    Paraffin embedded human spleen stained with Hamster anti Mouse Delta-Like protein 1 followed by Goat anti Hamster IgG:HRP
  • FC - Anti Mouse Delta-Like Protein 1 Antibody, clone HMD1-5  ABD12726
    Mouse Delta like protein 1 transfected cells stained with Hamster anti Mouse Delta like protein 1
  • FC - Anti Mouse Delta-Like Protein 1 Antibody, clone HMD1-5  ABD12726
    Mouse Delta like protein 1 transfected cells stained with Hamster anti Mouse Delta like protein 1:RPE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-F, FC, Func
Primary Accession Q61483
Other Accession O00548, P97677
Reactivity Mouse
Host Hamster
Clonality Monoclonal
Isotype IgG
Clone Names HMD1-5
Calculated MW 78449 Da
Additional Information
Other Species Rat
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen DLL1-expressing CHO cells.
Shelf Life 18 months from the date of despatch
Gene ID 13388
Other Names Delta-like protein 1, Drosophila Delta homolog 1, Delta1, Dll1
Target/Specificity Hamster anti Mouse Delta-Like Protein 1 antibody, clone HMD1-5 specifically recognizes Delta-like protein 1 (DLL1), one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. DLL1 is widely expressed, and acts as a mediator of cell fate decisions during hematopoiesis, and may play a role in cell-to-cell communication in mammalian embryos. DLL1 plays an important role in B and T cell differentiation, in embryonic somite formation and patterning, and associates with the scaffolding protein MAGI1 at adherens junctions on neuronal processes. Signaling through DLL1 and Notch 2 has been implicated in the development of marginal zone B cells (MZB). Hamster anti Mouse Delta-Like Protein 1 antibody, clone HMD1-5 blocks binding of Notch2 to Dll1 (Moriyamaet al.2008)
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Mouse Delta-Like Protein 1 Antibody, clone HMD1-5 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12726
(40 western blots)
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