|Application ||IHC-F, FC|
|Other Accession||P97607, Q9Y219|
|Calculated MW||134745 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Jagged2-expressing CHO cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Protein jagged-2, Jagged2, Jag2|
|Target/Specificity||Hamster anti Mouse JAGGED2 antibody, clone HMJ2-1 specifically recognizes Jagged2, one of the five major ligands of the Notch signaling pathway, which is activated through the binding of specific ligands to the Notch receptors Notch 1-4.The Notch signaling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell hematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and the gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signaling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Jagged2 is expressed by stromal and thymic lymphoid cells, and by splenic macrophages and dendritic cells (DCs), and plays a vital role during limb, craniofacial, tooth, and thymic development, as well as being implicated in the maintenance and function of neuronal cells in both the central (CNS) and enteric (gastrointestinal) nervous system. Studies have shown that the anti-tumor cytolytic activity of natural killer (NK) cells can be enhanced by Jagged2 stimulation, and that the vital role which DC Jagged2 expression plays in DC-mediated NK cell activation, may|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse JAGGED2 Antibody, clone HMJ2-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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