|Application ||WB, IHC-P, IF, FC, E|
|Calculated MW||59352 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Synthetic peptide derived from sequence situated on the extra-cellular domain of human calcitonin receptor.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Calcitonin receptor, CT-R, CALCR|
|Target/Specificity||Mouse anti Human Calcitonin Receptor antibody, clone 30/7-9B4 recognizes the human calcitonin receptor, a 508 amino acid multi pass transmembrane membrane glycoprotein with seven transmembrane domains, coupled to G protein messenger systems. The calcitonin receptor is expressed in kidney, central and peripheral nervous systems and on osteoclasts. It is also expressed in a number of tissues during the development of the embryo and may be important in foetal morphogenesis.Clone MAb 9B4 recognises an epitope within the extra-cellular domain, the epitope is common to both C1a and C1b human isoforms.Calcitonin receptor expression is elevated in the inflammatory cells associated with diseased arteries and atherosclerotic plaques (Wookeyet al.2009) expression has also been noted within malignant cells of glioblastoma multiforme (Wookeyet al.2012).Several different isoforms of the calcitonin receptor, a result of alternative splicing and promotor usage have been identified. Mouse anti Human Calcitonin Receptor antibody, clone 30/7-9B4 was raised against the canonical isoform 1 but has been shown to bind to a truncated isoform lacking the N-terminal region of the receptor (Qiet al.2012). The calcitonin receptor can associate with RAMP1, 2 and 3 to form discrete receptors for amylinMouse anti human calcitonin receptor antibody, clone 30/7-9B4 has been successfully used for the demonstrating calcitonin receptor on human cryostat tissue section by immunohistochemistry and western blotting (Wookeyet al.2012).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Calcitonin Receptor Antibody, clone 30/7-9B4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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