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Anti Human Siglec-7 Antibody, clone S7.7

Mouse Anti-Human Monoclonal Antibody

     
  • FC - Anti Human Siglec-7 Antibody, clone S7.7  ABD12786
    Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: FITC
  • FC - Anti Human Siglec-7 Antibody, clone S7.7  ABD12786
    Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: Endotoxin Low
  • FC - Anti Human Siglec-7 Antibody, clone S7.7  ABD12786
    Human peripheral blood lymphocytes stained with Mouse anti Human Siglec-7: RPE
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E, IP, Func
Primary Accession Q9Y286
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names S7.7
Calculated MW 51143 Da
Additional Information
Other Species Rh
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Siglec-7 3T3 transfected cells
Shelf Life 18 months from the date of despatch
Gene ID 27036
Other Names Sialic acid-binding Ig-like lectin 7, Siglec-7, Adhesion inhibitory receptor molecule 1, AIRM-1, CDw328, D-siglec, QA79 membrane protein, p75, CD328, SIGLEC7, AIRM1
Target/Specificity Mouse anti Human Siglec-7 antibody, cloneS7.7 recognizes human Sialic acid-binding Ig-like lectin 7, otherwise known as CD328, a putative adhesion molecule and member of the Ig superfamily, predominantly expressed by both resting and activated natural killer (NK) cells, and also at lower levels by monocytes, granulocytes, monocyte-derived macrophages and dendritic cells, and a small population of CD8+ memory T cells. Classed as a CD33-related Siglec, Siglec-7 preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid, and acts as a novel inhibitory receptor for NK cells, mediating the inhibition of NK cell cytotoxicity, and implicated in the regulation of NK cell and T cell activation, and hematopoiesis. Mouse anti Human Siglec-7 antibody, cloneS7.7 is a blocking antibody (Avrilet al.2006), and has been shown to recognize Siglec-7 in Rhesus monkey (Jaroenpoolet al.2007).
Preservative & Stabilisers None present
Storage Store at -20℃ only.
PrecautionsAnti Human Siglec-7 Antibody, clone S7.7 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12786
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