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>   home   >   Products   >   Primary Antibodies   >   Anti Human Siglec-10 Antibody, clone 5G6    

Anti Human Siglec-10 Antibody, clone 5G6

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti Human Siglec-10 Antibody, clone 5G6  ABD12787
    Siglec-10 tranfected CHO cells stained with Mouse anti Human siglec-10 followed by Rabbit F(ab')2 anti Mouse IgG:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96LC7
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 5G6
Calculated MW 76592 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Recombinant human Siglec-10, fused with the Fc region of human IgG
Shelf Life 18 months from date of despatch.
Gene ID 89790
Other Names Sialic acid-binding Ig-like lectin 10, Siglec-10, Siglec-like protein 2, SIGLEC10, SLG2
Target/Specificity Mouse anti Human Siglec-10 antibody, clone 5G6 recognises human Siglec-10 (Sialic acid-binding Ig-like lectin 10), a putative adhesion molecule and member of the Ig superfamily, expressed by monocytes, B cells, eosinophils, and at a higher level by a subpopulation of CD16+CD56- natural killer (NK) cells. Structurally, Siglec-10 is most similar to the CD33-related group of Siglecs, and preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid. Studies have shown that Siglec-10 acts as a substrate for VAP-1 (Vascular adhesion protein-1), a glycoprotein expressed on endothelium during inflammation, which is involved in primary amine oxidation and leucocyte trafficking, (Kiviet al.2009). This interaction between Siglec-10 and VAP-1, implicates Siglec-10 in endothelial lymphocyte adhesion and in the modulation of the inflammatory microenvironment. Studies have shown that clone 5G6 does not cross-react with Siglecs 3, 5, 7, 8 and 9 (Mundayet al.2001).
Preservative & Stabilisers 0.09% Sodium Azide, 1% Bovine Serum Albumin
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Siglec-10 Antibody, clone 5G6 is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD12787
(40 western blots)
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