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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Anti Human Siglec-5/Siglec-14 Antibody, clone 1A5    

Anti Human Siglec-5/Siglec-14 Antibody, clone 1A5

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti Human Siglec-5/Siglec-14 Antibody, clone 1A5  ABD12790
    Human peripheral blood monocytes stained with Mouse anti Human Siglec-5/Siglec-14 followed by rabbit F(ab')2 anti mouse IgG:FITC
  • FC - Anti Human Siglec-5/Siglec-14 Antibody, clone 1A5  ABD12790
    Human peripheral blood monocytes stained with Mouse anti Human Siglec-5/Siglec-14:FITC
  • FC - Anti Human Siglec-5/Siglec-14 Antibody, clone 1A5  ABD12790
    Human peripheral blood monocytes stained with Mouse anti Human Siglec-5/Siglec-14:RPE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q08ET2
Other Accession O15389
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 1A5
Calculated MW 43970 Da
Additional Information
Other Species Chimpanzee
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Siglec-5-Fc protein, consisting of the full-length extracellular region of human Siglec-5, fused with the Fc region of human IgG1.
Shelf Life 18 months from date of despatch.
Gene ID 100049587
Other Names Sialic acid-binding Ig-like lectin 14, Siglec-14, SIGLEC14
Target/Specificity Mouse anti Human Siglec-5/Siglec-14 antibody, clone 1A5recognizes human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage.Mouse anti Human Siglec-5/Siglec-14 antibody, clone 1A5, is one of several Siglec-5 antibodies which also recognises human Siglec-14 (Angataet al.2006). Siglec-14 shares an almost identical sequence with Siglec-5 within the first two Ig-like domains, indicating partial gene conversion between these two Siglecs, also evident in other primate species.Siglec-5 is also related to the myelomonocytic-derived adhesion molecule CD33 (Siglec-3), and mediates sialic-acid dependent binding to cells, as well as acting as an inhibitory receptor in the down-regulation of cell activation.Structurally, Siglec-5 contains an immunoreceptor tyrosine-based inhibitor motif (ITIM), which plays a part in the modulation of cellular responses, and when phosphorylated, can bind to the SH2 domain of several SH2-containing phosphatases. Siglec-14 is a putative sialic-acid binding adhesion molecule, and member of the Ig superfamily, predominantly expressed in hematopoietic tissues, which has been shown to associate with the activating adapter protein DAP12. Mouse anti Human Siglec-5/Siglec-14 antibody, clone 1A5 cross reacts with Chimpanzee (Jaroenpoolet al.2007).
Preservative & Stabilisers 0.09% Sodium Azide, 1% Bovine Serum Albumin
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Siglec-5/Siglec-14 Antibody, clone 1A5 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12790
(40 western blots)
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