|Application ||IF, FC, E, Func|
|Calculated MW||33361 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Hepatitis A virus cellular receptor 1 homolog, HAVcr-1, Kidney injury molecule 1, KIM-1, T cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, T cell membrane protein 1, T-cell immunoglobulin mucin receptor 1, TIM-1, Havcr1, Kim1, Tim1, Timd1|
|Target/Specificity||Rat anti Mouse TIM-1 antibody, clone RMT1-10 recognizes mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b).Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. Polymorphic forms of Tim-1 are associated with increased susceptibility to asthma, eczema and Rheumatoid arthritis.Rat anti Mouse TIM-1 antibody, clone RMT1-10 has been shown to promote Th2 responses, and inhibit antigen-specific T cell proliferation, in contrast to the agonistic function of many Tim-1 antibodies (Xiao et al. 2007).Rat anti Mouse TIM-1 antibody, clone RMT1-10 has been shown to reduce the severity of EAE (experimental autoimmune encephalomyelitis) and delay disease onset, in mice studies (Xiao et al. 2007).|
|Preservative & Stabilisers||None present|
|Storage||Store at -20℃ only.|
|Precautions||Anti Mouse TIM-1 Antibody, clone RMT1-10 is for research use only and not for use in diagnostic or therapeutic procedures.|
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