|Application ||WB, FC, IP, Func|
|Calculated MW||33504 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Tim-2-Ig, consisting of amino acids 1-230 of mouse Tim-2, coupled with the Fc portion of mouse IgG2a.|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell immunoglobulin and mucin domain-containing protein 2, TIMD-2, T-cell immunoglobulin mucin receptor 2, TIM-2, T-cell membrane protein 2, Timd2, Tim2|
|Target/Specificity||Rat anti Mouse TIM-2 antibody, clone RMT2-25 recognizes mouse Tim-2 (T-cell immunoglobulin mucin 2), a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells.Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.Studies using Rat anti Mouse TIM-2 antibody, clone RMT2-25 in mouse, have shown that signaling by Tim-2 can influence the proliferation and antibody production of B cells, during early phase collagen-induced arthritis (Kawamoto et al. 2011).Rat anti Mouse TIM-2 antibody, clone RMT2-25 has been shown to significantly enhance the proliferation of stimulated splenic B cells in vitro(Kawamoto et al. 2011).|
|Preservative & Stabilisers||None present|
|Storage||Store at -20℃ only.|
|Precautions||Anti Mouse TIM-2 Antibody, clone RMT2-25 is for research use only and not for use in diagnostic or therapeutic procedures.|
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