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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti Mouse TIM-3 Antibody, clone RMT3-23    

Anti Mouse TIM-3 Antibody, clone RMT3-23

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti Mouse TIM-3 Antibody, clone RMT3-23  ABD12794
    Tim-3 transfected LY5178Y cells stained with Rat anti Mouse TIM-3:Low Endotoxin
  • FC - Anti Mouse TIM-3 Antibody, clone RMT3-23  ABD12794
    Tim-3 transfected LY5178Y cells stained with Rat anti Mouse TIM-3:FITC
  • FC - Anti Mouse TIM-3 Antibody, clone RMT3-23  ABD12794
    Tim-3 transfected LY5178Y cells stained with Rat anti Mouse TIM-3
  • FC - Anti Mouse TIM-3 Antibody, clone RMT3-23  ABD12794
    Tim-3 transfected LY5178Y cells stained with Rat anti Mouse TIM-3:RPE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IHC-F, IF, FC, Func
Primary Accession Q8VIM0
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names RMT3-23
Calculated MW 30934 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Tim-3-Ig, consisting of amino acids 1-191 of mouse Tim-3, coupled with the Fc portion of mouse IgG2a.
Shelf Life 18 months from date of despatch.
Gene ID 171285
Other Names Hepatitis A virus cellular receptor 2 homolog, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, Havcr2, Tim3, Timd3
Target/Specificity Rat anti Mouse Tim-3 antibody, clone RMT3-23 specifically recognizes mouse T-cell immunoglobulin mucin 3, a transmembrane glycoprotein and member of the immunoglobulin superfamily, preferentially expressed by differentiated CD4+ Th1 cells and CD8+ Tc1 (cytotoxic) cells, but not by CD4+ Th2 cells or CD8+ Tc2 cells.Tim-3 acts as a negative regulator of Th1-mediated inflammatory diseases including GVHD, type I diabetes, and EAE (experimental autoimmune encephamyelitis), promotes immunological tolerance, and is a receptor for galectin-9, shown to induce cell death of Th1 cells in vitro. Tim-3 is also involved in the regulation of macrophage activation, acts as a phagocytic receptor, and has been shown to recognize apoptotic cells via the IgV domain.Studies have shown thatRat anti Mouse Tim-3 antibody, clone RMT3-23 significantly inhibits the efficient phagocytosis of apoptotic cells by PEMs (peritoneal exudate Mac1+ cells) (Nakayama et al. 2009).
Preservative & Stabilisers None present
Storage Store at -20℃ only.
PrecautionsAnti Mouse TIM-3 Antibody, clone RMT3-23 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12794
(40 western blots)
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