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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti Mouse TIM-4 Antibody, clone RMT4-54    

Anti Mouse TIM-4 Antibody, clone RMT4-54

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti Mouse TIM-4 Antibody, clone RMT4-54  ABD12795
    Mouse TIM-4 transfected NRK cells stained with Rat anti Mouse TIM-4:RPE
  • FC - Anti Mouse TIM-4 Antibody, clone RMT4-54  ABD12795
    Mouse TIM-4 transfected NRK cells stained with Rat anti Mouse TIM-4
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, FC, Func
Primary Accession Q6U7R4
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names RMT4-54
Calculated MW 37548 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Tim-4-Ig, consisting of amino acids 1-288 of mouse Tim-4, coupled with the Fc portion of mouse IgG2a.
Shelf Life 18 months from the date of despatch
Gene ID 276891
Other Names T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, Spleen, mucin-containing, knockout of lymphotoxin protein, SMUCKLER, T-cell immunoglobulin mucin receptor 4, TIM-4, T-cell membrane protein 4, Timd4, Tim4
Target/Specificity Rat anti Mouse TIM-4 antibody, clone RMT4-54 recognizes mouse Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily, exclusively expressed by antigen-presenting cells, which acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production.Tim-4 is reported to be crucial for the phagocytosis of apoptotic cells by peritoneal macrophages, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on DCs, enhances Th2 cell function. The TIM-4 gene locus is associated with predisposition to asthma in both mice and humans and may be considered as a candidate disease gene for asthma.Clone RMT4-54 significantly inhibits the efficient phagocytosis of apoptotic cells by PRMs (peritoneal resident Mac1+ cells), but not PEMs (peritoneal exudate Mac1+ cells) (Nakayama, M. et al. 2009).
Preservative & Stabilisers None present
Storage Store at -20℃ only.
PrecautionsAnti Mouse TIM-4 Antibody, clone RMT4-54 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12795
(40 western blots)
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