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Anti Human CD49f Antibody, clone NKI-GoH3

Rat Anti-Human Monoclonal Antibody

  • FC - Anti Human CD49f Antibody, clone NKI-GoH3  ABD12840
    Staining of human peripheral blood lymphocytes with Rat anti Human CD49f:Biotin
  • FC - Anti Human CD49f Antibody, clone NKI-GoH3  ABD12840
    Staining of human peripheral blood platelets with Rat anti Human CD49f:Biotin
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23229
Reactivity Human
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names NKI-GoH3
Calculated MW 126606 Da
Additional Information
Other Species M,Dog,Pig,Cynomolgus monkey,Sh
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen BALB/c mouse mammary tumour cells.
Shelf Life 18 months from date of despatch.
Gene ID 3655
Other Names Integrin alpha-6, CD49 antigen-like family member F, VLA-6, CD49f, Integrin alpha-6 heavy chain, Integrin alpha-6 light chain, Processed integrin alpha-6, Alpha6p, ITGA6
Target/Specificity Rat anti Human CD49f antibody, clone NKI-GoH3 recognizes CD49F (VLA-6 alpha chain), a ~120 kDa cell surface glycoprotein that can form distinct complexes with CD29 (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Clone NKI-GoH3 reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukaemia cells (alpha-6 beta-1). In immunohistology the monoclonal antibody reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytotrophoblasts.VLA-6 is an important mediator of cell binding to laminin. Studies suggest that clone NKI-GoH3 specifically blocks the binding of cells to the E8 fragment of laminin (Sonnenberget al.1998).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human CD49f Antibody, clone NKI-GoH3 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12840
(40 western blots)
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