|Application ||WB, IHC-F, FC, IP|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Sheep T cells.|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti Sheep MHC Class I monoclonal antibody, clone VPM19 recognizes the ovine homologue of the human MHC Class I, a monomorphic determinant expressed on the heavy chain of sheep MHC Class I, (OLA Class I).The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In sheep, this is often referred to as the ovine leukocyte antigen (OLA) region. Ovine MHC Class I functions in the recognition and presentation of foreign antigens to T-cells.Ovine MHC Class I is a membrane glycoprotein with a molecular weight of approximately 44kDa, expressed on the cell surface of all peripheral blood leucocytes.Clone VPM19 has been in used in studies on a number of domestic animal diseases, in particular Maedi Visna virus infection, a disease of significant inportance in commercial sheep flocks (Leeet al.1996,Ryanet. al.2000andWuet. al.2008). Clone VPM19 has been cited as recognising MHC class I in some other species and has been used in a study of Feline herpes virus infection (Montagnaroet. al.2009).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Sheep MHC Class I Antibody, clone VPM19 is for research use only and not for use in diagnostic or therapeutic procedures.|
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