|Application ||IHC-F, FC|
|Calculated MW||114900 Da|
|Purification||Purified IgG prepared by ion exchange chromatography|
|Immunogen||HOON pre-B leukaemia cell line.|
|Shelf Life||18 months from the date of despatch|
|Other Names||Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha, CD49d, ITGA4, CD49D|
|Target/Specificity||Mouse anti Human CD49d monoclonal antibody, clone 44H6 recognizes human CD49d also known as integrin alpha-4 or VLA-4 subunit alpha. CD49d is a ~150kDa single pass type 1 transmembrane glycoprotein with seven FG-GAP repeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa (Hemleret al.1987). CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form The Peyer patches-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue (Sackstein 2006) through its interaction with MadCam-1, preferentially expressed on Peyer’s patch high endothelial venules and postcapillary venules in lamina propria (Briskinet al.1997)Mouse anti human CD49d, clone 44H6 is reported to induce homotypic aggregation of pre-B cell lines including HOONandNALM-6(Letarteet al.1993).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4oC or at -20oC if preferred.|
|Precautions||Anti Human CD49d Antibody, clone 44H6 is for research use only and not for use in diagnostic or therapeutic procedures.|
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