|Application ||IHC-F, IF, FC|
|Calculated MW||182979 Da|
|Purification||Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serumPurified IgG prepared by affinity chromatography on Protein G from tissue culture supernatantPurified IgG prepared by affinity chromatography on Protein G from tissue cul|
|Immunogen||Stromal (reticular) elements from spleen.|
|Shelf Life||18 months from the date of despatch|
|Other Names||Sialoadhesin, Sheep erythrocyte receptor, SER, Sialic acid-binding Ig-like lectin 1, Siglec-1, CD169, Siglec1, Sa, Sn|
|Target/Specificity||Rat anti Mouse CD169, clone MOMA-1 recognizes murine CD169, also known as sialoadhesin or Siglec-1. CD169 is a lectin-like receptor expressed by certain populations of macrophages including marginal zone metallophils of the spleen, subcapsular macrophages of lymph nodes and stromal macrophages in bone marrow (Morriset al.1991).CD169 is a ~185 kDa sialic acid binding receptor containing 17 immunoglobulin-like domains (Crockeret al.1992). Expression of CD169 can be induced on macrophages in culture by a serum factor and further modulated by cytokine exposure (McWilliamet al.1992).Rat anti mouse CD169, clone MOMA-1 has been used for the in vivo depletion of specific macrophage populations (Kraalet al.1988).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse CD169 Antibody, clone MOMA-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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