|Application ||WB, E|
|Calculated MW||267009 Da|
|Shelf Life||18 months from date of despatch.|
|Other Names||Coagulation factor VIII, Antihemophilic factor, AHF, Procoagulant component, Factor VIIIa heavy chain, 200 kDa isoform, Factor VIIIa heavy chain, 92 kDa isoform, Factor VIII B chain, Factor VIIIa light chain, F8, F8C|
|Target/Specificity||Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/5 recognizes human Factor VIII, an essential blood coagulation factor. Factor VIII is primarily synthesized in the liver and is secreted into the bloodstream where it forms a complex with von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which in turn activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause haemophilia A, a disorder characterised by the body’s inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Mouse anti Human Factor VIII antibody, clone RFF-VIIIC/5 recognizes an epitope towards the C-terminus of full-length Factor VIII. It also recognizes the 80 kDa and 70 kDa cleavage products.|
|Preservative & Stabilisers||None present|
|Storage||Store at -20℃ only.|
|Precautions||Anti Human Factor VIII Antibody, clone RFFVIIIC/5 is for research use only and not for use in diagnostic or therapeutic procedures.|
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