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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti Sheep CD230 Antibody, clone 5121    

Anti Sheep CD230 Antibody, clone 5121

Mouse Anti-Sheep Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23907
Reactivity Sheep
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 5121
Calculated MW 27915 Da
Additional Information
Other Species B
Purification Purified IgG prepared by affinity chromatography on Protein A
Shelf Life 18 months from date of despatch.
Gene ID 493887
Other Names Major prion protein, PrP, CD230, PRNP, PRP, SIP
Target/Specificity Mouse anti Sheep CD230, clone 5121, recognises the ovine homologue of CD230.CD230, also known as prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.Clone 5121 will recognise both PrPc and PrPSc. After denaturation/protease treatment this antibody recognises only the disease-associated form (PrPSc).Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques.
Preservative & Stabilisers 0.09% Sodium azide
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Sheep CD230 Antibody, clone 5121 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12965
(40 western blots)
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