|Application ||WB, IHC-P, E|
|Calculated MW||27915 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Shelf Life||18 months from date of despatch.|
|Other Names||Major prion protein, PrP, CD230, PRNP, PRP, SIP|
|Target/Specificity||Mouse anti Sheep CD230, clone 5121, recognises the ovine homologue of CD230.CD230, also known as prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.Clone 5121 will recognise both PrPc and PrPSc. After denaturation/protease treatment this antibody recognises only the disease-associated form (PrPSc).Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques.|
|Preservative & Stabilisers||0.09% Sodium azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Sheep CD230 Antibody, clone 5121 is for research use only and not for use in diagnostic or therapeutic procedures.|
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