|Application ||WB, IHC-F, IF, FC, E|
|Clone Names||RYR.1 (G-1)|
|Immunogen||Short synthetic polypeptide corresponding to the C-terminal domain of the ryanodine receptor.|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 recognizes the human ryanodine receptor 1, also known as Skeletal muscle calcium release channel or skeletal muscle ryanodine receptor. Ryanodine receptor 1 is a is a large 5038 amino acid ~500kDa multi pass sarcoplamic reticulum associated transmembrane protein containing three B30.2/SPRY domains and five MIR domains. Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 recognizes an epitope within the C-terminal cytoplasmic domain of the ryanodine receptor (UniProt: P21817).Ryanodine receptors have been shown to play critical roles in the intracellular Ca2+ signaling occurring during cell activation in muscle cells and non-muscle cells. Mouse anti Human Ryanodine Receptor antibody, clone RYR-1 reacts with ryanodine receptor isolated from a variety of cell types (e.g. lymphocytes, macrophages, granulocytes, fibroblasts, epithelial, endothelial cells, skeletal muscle, cardiac muscle and brain tissues). Defects in the ryanodine receptor 1 gene are associated with malignant hyperthermia (Gillardet al.1992), central core disease of muscle (Quaneet al.1993) and certain congential myopathies (Monnieret al.2000).|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Ryanodine Receptor Antibody, clone RYR.1 (G-1) is for research use only and not for use in diagnostic or therapeutic procedures.|
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