|Application ||WB, IHC-P|
|Calculated MW||61149 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Polypeptide from the 50 kDa subunit of heparanase.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Heparanase, 188.8.131.52, Endo-glucoronidase, Heparanase-1, Hpa1, Heparanase 8 kDa subunit, Heparanase 50 kDa subunit, HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1|
|Target/Specificity||Mouse anti Human Heparanase-1 antibody, clone HP3/17 recognizes heparanase-1, also know as HPA1, an endo-beta-D-glucuronidase that degrades heparan sulfate proteoglycans (HSPGs) in the extracellular matrix through cleavage of the heparan sulfate side chains. Heparanase-1 is a heterodimer that is produced as a 65 kDa latent precursor, consisting of an 8 kDa subunit, a 50 kDa subunit and a linker peptide. Activation of Heparanase-1 occurs through cleavage of the linker peptide, releasing the 8 kDa subunit from the active 50 Da subunit.Mouse anti Heparanase-1 has been reported to recognize heparanase-1 in xenopus by western blotting (Bertolesiet al.2008)|
|Preservative & Stabilisers||0.01% Thiomersal|
|Storage||Store at -20℃ only.|
|Precautions||Anti Human Heparanase-1 Antibody, clone HP3/17 is for research use only and not for use in diagnostic or therapeutic procedures.|
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