|Calculated MW||26266 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Synthetic peptide corresponding to amino acids 41-54 (GAAPAPGIFSSQPG) of the native molecule conjugated to Keyhole Limpet Haemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Apoptosis regulator Bcl-2, BCL2|
|Target/Specificity||Rabbit anti Human Bcl-2 antinody recognizes human Bcl-2, a 239 amino acid ~25 kDa integral outer mitochondrial membrane protein that blocks apoptotic death in a variety of cell systems. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1). Bcl-2 is antiproliferative by facilitating G0entry.Constitutive expression of Bcl-2 is thought to be the cause of follicular lymphoma, also known as type II chronic lymphatic leukaemia. Bcl-2 mutations have also been found in Non-Hodgkin Lymphomas.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Bcl-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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