|Application ||IF, E|
|Calculated MW||47651 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Shelf Life||18 months from date of despatch.|
|Other Names||Alpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24/25 protein, Serpin A3, Alpha-1-antichymotrypsin His-Pro-less, SERPINA3, AACT|
|Target/Specificity||Sheep anti Human alpha 1 antichymotrypsin antibody detects human alpha 1 antichymotrypsin (AACT), a member of the serpin superfamily of serine proteinase inhibitors. AACT has a molecular weight of ~68kDa, and functions to protect the lower respiratory tract from proteolytic damage by inhibiting chymotrypsin-like proteinases, and also plays a role in the acute phase response.Polymorphisms in AACT appear to be tissue specific and influence protease targeting, and mutations in its gene have been implicated in the pathogenesis of Alzheimer's disease (AD). AACT levels are elevated in the cerebrospinal fluid of AD patients and elevated levels are also associated with AD severity.|
|Preservative & Stabilisers||0.09% Sodium Azide, 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Alpha 1 Antichymotrypsin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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