|Calculated MW||20187 Da|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Interleukin-7, IL-7, IL7|
|Target/Specificity||Rat anti Human Interleukin-7 antibody, clone BVD10-11C10 recognizes human interleukin 7 (IL-7), also known as Lymphopoietin 1 or pre-B cell factor. IL-7 is a 177 amino acid haematopoietic growth factor stimulating primarily early B and T lymphocytes. IL- 7 is required for development of T-cells in the thymus (Plumet al.1996) and absence of the IL-7 receptor α chain (CD127) leads to a severe combined immunodeficiency condition through the lack of T-cell production (Roifmanet al.2000). IL-7 is also important post-thymically for homeostasis of naive T-cell populations and generation and survival of CD4+ memory T-cells (Kondracket al.2003).IL-7 deficiency or deficient function is also noted in immunodeficiency diseases including rheumatoid arthritis (Leonard 2005), chronic colitis (Totsukaet al.2007). multiple sclerosis through CD127 (Svejgaard 2008) and diabetes (Liet al.2011).Rat anti Human Interleukin-7 antibody, clone BVD10-11C10 in biotinylated format has been used sucessfully in the development of a sensitive ELISA assay as a detection reagent for human IL-7. It has been shown to recognize both native and recombinant human IL-7, in conjunction with clone BVD10-40F6 as a capture reagent.|
|Preservative & Stabilisers||0.09% Sodium azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Interleukin-7 Antibody, clone BVD10-11C10 is for research use only and not for use in diagnostic or therapeutic procedures.|
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