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Anti Human Chymotrypsin Antibody, clone 4E1

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti Human Chymotrypsin Antibody, clone 4E1  ABD13173
    Published customer image:Mouse anti Human chymotrypsin antibody, clone 4E1 used for the detection of chrmtrypsinin in muse tissues by immunofoistochemistryImage caption:Endocrine and exocrine compartments destruction in the pancreas of Pdx1-Cre;LSL-KrasG12D;Tif1γlox/loxmice. Wild-type (A–C') and Pdx1-Cre; LSL-KrasG12D; Tif1?lox/lox (D–L') pancreas sections were stained with HPS (A,D,G,J), immuno-revealed either with an anti-chymotrypsin antibody (B,E,H,K) or an anti-insulin antibody (C,F,I,L and C',F',I',L' that represent the boxed region in C,F,I,L at a higher magnification). For Pdx1-Cre;LSL-KrasG12D;Tif1γlox/lox mice, analysis were performed at different ages. Number of mice: 3 weeks, n?=?3; 6–13 weeks, n?=?5; 18–27 weeks, n?=?4. Boxes: Higher magnification. The pictures show one representative mouse for each group.From: Vincent DF, Yan K-P, Treilleux I, Gay F, Arfi V, Kaniewsky B, et al. Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas.PLoS Genet 5(7): e1000575.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99895
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG3
Clone Names 4E1
Calculated MW 29484 Da
Additional Information
Other Species M,Rat
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Purified human pancreatic chymotrypsin.
Shelf Life 18 months from date of despatch.
Gene ID 11330
Other Names Chymotrypsin-C,, Caldecrin, CTRC, CLCR
Target/Specificity Mouse anti Human chymotrypsin antibody, clone 4E1recognizes human chymotrypsin-C, also known as chymotrypsin or caldecrin. Chymotrypsin is a 239 amino acid ~30 kDa protease with an additional 13 amino acid propeptide region and a 16 amino acid signal peptide.Variations in the CTRC gene has been associated with susceptibility to hereditary, pancreatitis (PCTT), a disease characterized by pancreatic inflammation and destruction of the parenchyma (Beeret al.2013).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Chymotrypsin Antibody, clone 4E1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13173
(40 western blots)
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