|Application ||IHC-P, IF, E|
|Other Accession||Q9QZS0, P08122, Q9QZR9|
|Calculated MW||160679 Da|
|Purification||Purified IgG prepared by antigen column chromatography|
|Immunogen||Collagen IV purified from mouse EHS tumor.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Collagen alpha-1(IV) chain, Arresten, Col4a1|
|Target/Specificity||Rabbit amti Mouse Collagen IV antibody recognizes mouse collagen type IV. Collagen IV is a 1682 amino acid ~160kDa (predicted) matrx protein and major component of glomerular basement membranes. Multiple isoforms exist each capable of forming triple helical structures with two other chains to form the type IV collagen network. The collagen IV alpha chain can be cleaved between residues 1444-1445 to yield the c-terminal 225 amino acid, ~28kDa arresten fragment, collagen α2(IV) yields a c-terminal canstatin fragment while Collagen α3(IV) yeilds a tumstatin fragment. Collagen IV bears a single collagen IV NC1 (C-terminal non-collagenous) domain (UniProt: Q9QZR9).Mutations in collagen IV genes have been implicated in inherited nephropathies and potentially in cystic kidney disease and intracranial aneurysms (Plaisieret al.2007).Rabbit amti Mouse Collagen IV antibody has been successfully employed for the detection of collagen IV by immunofluorescence and immunohistochemistry in mice (e.g. Tanget al.), rats (Shenet al.2014) and oragutan (Bredieset al.2013).The following cross reactivities have been observed:Mouse type IV100%Mouse types I, II & III|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Mouse Collagen IV Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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