|Calculated MW||45205 Da|
|Immunogen||Human haptoglobulin purified from serum.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP|
|Target/Specificity||Sheep anti Human haptoglobin antibody recognizes human haptoglobulin, a plasma protein that has high affinity for hemoglobin and is responsible for its capture and hepatic recycling. This process also acts to prevent kidney damage where hemoglobin would otherwise accumulate prior to excretion in the urine. Haptoglobin/hemoglobin complexes are cleared from the circulation in the liver by Kuppfer cells expressing the CD163 scavanger receptor.Two isoforms of human haptoglobin produced by alternative splicing have been described. Sheep anti Human haptoglobin antibody (ABD13252) binds to the canonical isoform 1 of human haptoglobin, binding to the truncated (missing residues 38-96) isoform 2 has not been evaluated.Mutation of the HP gene can lead to the development of Anhaptoglobinemia (AHP), a disease characterized by an absence of serum haptoglobin (Teyeet al.2004).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Haptoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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