|Application ||WB, E|
|Calculated MW||18737 Da|
|Immunogen||Peptide with sequence C-DIKDRSTLGEK from C-terminal of Cofilin 2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Cofilin-2, Cofilin, muscle isoform, CFL2|
|Target/Specificity||ABD13257 detects an epitope within the C-terminal (CT) of cofilin 2, an 18kD protein which is involved in the regulation of actin assembly in developing myotubes through the reversible control of actin polymerization and depolymerization. Cofilin 2 is the major component of intranuclear and cytoplasmic actin rods. Cofilin 2 is expressed in developing skeletal muscle at early foetal stages through to a young postnatal stage. During postnatal development, cofilin 1 expression in muscle is down-regulated and cofilin 2 becomes the only isoform in mature skeletal muscle. The onset of cofilin 2 expression is coupled with terminal differentiation of muscle cells. It is suggested that cofilin 2 could be associated with actin filaments in muscle cells more efficiently than cofilin 1.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Cofilin 2 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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