|Application ||WB, E|
|Calculated MW||72066 Da|
|Immunogen||Peptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tyrosine-protein kinase SYK, 188.8.131.52, Spleen tyrosine kinase, p72-Syk, SYK|
|Target/Specificity||Goat anti Syk antibody detects an epitope within the internal region of SYK, a ~70 kDa non-receptor protein tyrosine kinase whose role differs in haematopoietic and non haematopoietic stem cells. In haematopoietic cells SYK is involved in the proximal signalling downstream of activated immunoreceptors (BCR, TCR, Fc receptors), thereby orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis.In epithelial cells SYK appears to function as a negative regulator of related events. Furthermore, SYK has been shown to promote expression or secretion of inflammation-related molecules in lung epithelial cells. SYK appears to be required for vascular integrity during development, thus, manipulation of SYK function in endothelial cells could potentially modulate tumour-associated angiogenesis. SYK also has been shown to interact with Epstein-Barr virus LMP2A.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Syk Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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