|Application ||WB, E|
|Calculated MW||93021 Da|
|Immunogen||Peptide with sequence LQRQNRVDSKETEC from the C-terminus of CD156b.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, 18.104.22.168, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM17, CSVP, TACE|
|Target/Specificity||Goat anti Human CD156b antibody detects an epitope within the C-terminus of isoform 1 of CD156b, a ~125 kDa type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family. CD156b functions as a tumour necrosis factor-alpha converting enzyme (TACE). CD156b also causes a number of inflammatory modulators to undergo ectodomain shedding, including TNFR75, IL-1RII, TNFR55, L-selectin, and the amyloid precursor protein among others. CD156b plays a prominent role in the activation of the Notch signalling pathway.ADAM17 plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, and establishing an autocrine signaling pathway through endogenous EGFR activation. CD156b is therefore a prospective therapeutic target in human cancer.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD156b (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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