|Application ||WB, E|
|Calculated MW||93021 Da|
|Immunogen||Peptide with sequence LQRQNRVDSKETEC from the C-terminus of CD156b.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, 22.214.171.124, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b, ADAM17, CSVP, TACE|
|Target/Specificity||Goat anti Human CD156b antibody detects an epitope within the C-terminus of isoform 1 of CD156b, a ~125 kDa type I transmembrane glycoprotein which belongs to the ADAM (a disintegrin and metalloprotease domain) family. CD156b functions as a tumour necrosis factor-alpha converting enzyme (TACE). CD156b also causes a number of inflammatory modulators to undergo ectodomain shedding, including TNFR75, IL-1RII, TNFR55, L-selectin, and the amyloid precursor protein among others. CD156b plays a prominent role in the activation of the Notch signalling pathway.ADAM17 plays a pivotal role in several acquired tumor cell capabilities by mediating the availability of soluble transforming growth factor-alpha, and establishing an autocrine signaling pathway through endogenous EGFR activation. CD156b is therefore a prospective therapeutic target in human cancer.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD156b (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.