|Application ||WB, E|
|Calculated MW||51530 Da|
|Immunogen||Peptide sequence NKPITPSTYVRC corresponding to the N-terminal of IRAK4 (NP_057207.1).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interleukin-1 receptor-associated kinase 4, IRAK-4, 220.127.116.11, Renal carcinoma antigen NY-REN-64, IRAK4|
|Target/Specificity||ABD13263 detects an epitope within the N-terminal (NT) region of integrin-1 receptor-associated kinase 4 (IRAK4). IRAK4 has a molecular weight of 50kD, and is an important mediator in the signal transduction of Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family members. IRAK4 functions in this signal transduction pathway by binding to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signalling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK4 is a key activator of TLR-mediated signal transductions and has crucial roles in innate immune responses. It is expressed by the liver, kidneys and skeletal muscle.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti IRAK4 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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