|Calculated MW||119233 Da|
|Immunogen||Synthetic 16 amino acid peptide for the internal domain of human focal adhesion kinase.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Focal adhesion kinase 1, FADK 1, 188.8.131.52, Focal adhesion kinase-related nonkinase, FRNK, Protein phosphatase 1 regulatory subunit 71, PPP1R71, Protein-tyrosine kinase 2, p125FAK, pp125FAK, PTK2, FAK, FAK1|
|Target/Specificity||Rabbit anti Human Focal Adhesion Kinase antibody recognizes human focal adhesion kinase 1, also known as Focal adhesion kinase-related nonkinase, Protein phosphatase 1 regulatory subunit 71 or Protein-tyrosine kinase 2. Focal adhesion kniase belongs to the Tyr protein kinase family and contains a single FERM domain and a single protein kinase domain. Rabbit anti Human Focal Adhesion Kinase antibody detects an epitope within the internal region of Focal adhesion kinase (FAK), a 125kD cytoplasmic protein tyrosine kinase that is activated by numerous stimuli and controls cell motility, proliferation and apoptosis. FAK resides at focal adhesions that form between cells growing in the presence of extracellular matrix constituents (Brami-Cherrieret al.2014).FAK is a highly conserved molecule amongst vertebrate species and the immunogen sequence domonstrates 100% identity with mouse, rat, many non-human primates, bovine, rabbit and chicken species.FAK plays a potential role in oncogenic transformation, and its expression is thought to be correlated to tumour invasiveness (Ibbetsonet al.2013).|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Focal Adhesion Kinase Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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