|Calculated MW||146808 Da|
|Immunogen||Synthetic peptide: Internal domain of human ErbB4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Receptor tyrosine-protein kinase erbB-4, 220.127.116.11, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4, ERBB4, HER4|
|Target/Specificity||ABD13269 detects an epitope within the internal region of human ErbB4, a transmembrane protein which is a member of the epidermal growth factor receptor subfamily. ErbB4 is activated by a number of factors including neuregulins and betacellulin, which leads to the cleavage of a 120kD ectodomain fragment by TACE. In the cell, the remaining 80kD fragment of ErbB4 is internalised and cleaved by gamma-secretase. This fragment translocates to the nucleus and induces cell proliferation and differentiation.ErbB4 is important in embryonic development, and mutations to its gene have been associated with cancer.|
|Preservative & Stabilisers||0.1%Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human ErbB4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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