|Calculated MW||26183 Da|
|Immunogen||A synthetic peptide corresponding to an internal domain of human UCH-L3, conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ubiquitin carboxyl-terminal hydrolase isozyme L3, UCH-L3, 126.96.36.199, Ubiquitin thioesterase L3, UCHL3|
|Target/Specificity||Rabbit anti Human UCH-L3 antibody detects an epitope within the internal domain of human ubiquitin C-terminal hydrolase L3 (UCH-L3), a ~26 kDa thiol protease that hydrolyses a peptide bond in ubiquitin and nedd8. UCH-L3 and the closely related UCH-L1 are thought to recycle ubiquitin to maintain pools of monomeric ubiquitin necessary for proteolysis. UCH-L1 and UCH-L3 have been shown to have separate and overlapping functions in the maintanence of neurons of the gracile tract, nucleus tractus solitarius (NTS) and area postrema (AP). UCH-L3 defective mice have a learning deficit compared to wild type littermates, and significantly increased working memory errors (Woodet al2005).|
|Preservative & Stabilisers||0.09%Sodium Azide|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human UCH-L3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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