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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti Human Phosphodiesterase 1C (C-Terminal) Antibody    

Anti Human Phosphodiesterase 1C (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC-P - Anti Human Phosphodiesterase 1C (C-Terminal) Antibody  ABD13273
    Staining of formalin fixed, paraffin embedded human thyroid with Rabbit anti Human phosphodiesterase 1C
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14123
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 80760 Da
Additional Information
Immunogen Synthetic peptide: C-terminal domain of human phosphodiesterase 1C conjugated to KLH.
Shelf Life 18 months from date of despatch.
Gene ID 5137
Other Names Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1C, Cam-PDE 1C,, hCam-3, PDE1C
Target/Specificity ABD13273 detects an epitope within the C-terminal (CT) region of phosphodiesterase 1C (PDE1C), a subtype of the PDE1 enzyme. PDE1C is activated by calmodulin binding in the presence of calcium, and degrades the cyclic nucleotides cAMP and cGMP. A number of PDE1C isoforms exist, each with different affinities for cAMP and cGMP. They have a range of molecular weights from 65-70kD. PDE1C is a major regulator of smooth muscle cell (SMC) proliferation in humans, and plays an important role in the development of organs containing smooth muscle. PDE1C may also have a role in olfaction, regulation of sperm function and neuronal signaling. Inhibition of PDE1C may prove beneficial in the treatment of diseases such as atherosclerosis and pulmonary hypertension where excessive SMC proliferation occurs.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Phosphodiesterase 1C (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13273
(40 western blots)
Availability: Inquire
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