|Calculated MW||80760 Da|
|Immunogen||Synthetic peptide: C-terminal domain of human phosphodiesterase 1C conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1C, Cam-PDE 1C, 188.8.131.52, hCam-3, PDE1C|
|Target/Specificity||ABD13273 detects an epitope within the C-terminal (CT) region of phosphodiesterase 1C (PDE1C), a subtype of the PDE1 enzyme. PDE1C is activated by calmodulin binding in the presence of calcium, and degrades the cyclic nucleotides cAMP and cGMP. A number of PDE1C isoforms exist, each with different affinities for cAMP and cGMP. They have a range of molecular weights from 65-70kD. PDE1C is a major regulator of smooth muscle cell (SMC) proliferation in humans, and plays an important role in the development of organs containing smooth muscle. PDE1C may also have a role in olfaction, regulation of sperm function and neuronal signaling. Inhibition of PDE1C may prove beneficial in the treatment of diseases such as atherosclerosis and pulmonary hypertension where excessive SMC proliferation occurs.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Phosphodiesterase 1C (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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