|Calculated MW||105717 Da|
|Immunogen||Synthetic peptide: N-terminal region of human phosphodiesterase 2A conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||cGMP-dependent 3', 5'-cyclic phosphodiesterase, 22.214.171.124, Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE, PDE2A|
|Target/Specificity||Rabbit anti human phosphodiesterase 2A (N-terminal) antibody detects an epitope within the N-terminal (NT) region of phosphodiesterase 2A (PDE2A), a 100kD cyclic nucleotide phosphodiesterase (PDE). Three isoforms of PDE2A have been reported (PDE2A1, PDE2A2, and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy.PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localised in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Phosphodiesterase 2A (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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