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Rabbit Anti-Human Polyclonal Antibody
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- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P20702 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 127829 Da |
| Immunogen | Synthetic peptide: Internal domain of human CD11c, conjugated to KLH. |
|---|---|
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 3687 |
| Other Names | Integrin alpha-X, CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, 95, CD11c, ITGAX, CD11C |
| Target/Specificity | Rabbit anti Human CD11c antibodydetects human CD11c, also known as integrin alpha X (ITGAX). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. CD11c combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). CD11c is ~150 kDa in size, and is expressed predominantly on tissue macrophages and dendritic cells.CD11c binds a myriad of ligands including cell adhesion molecules (e.g. ICAM-1, ICAM-4), bacterial cell wall components (LPS), complement protein (iC3b), and matrix proteins such as fibrinogen and collagen. In light of this, CD11c has a number of functions including phagocytosis, cell migration, and cytokine production by macrophages/monocytes, as well as induction of T cell proliferation by Langerhans cells. |
| Preservative & Stabilisers | 0.1%Sodium Azide (NaN3) |
| Storage | Store at +4℃ or at -20℃ if preferred. |
| Precautions | Anti Human CD11c Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Research Areas
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Application Protocols
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Cat# ABD13287
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