|Calculated MW||87058 Da|
|Immunogen||Synthetic peptide: N-terminal domain of human CD61, conjugated to KLH.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIa, CD61, ITGB3, GP3A|
|Target/Specificity||Rabbit anti human CD61 (N-terminal) antibody detects an epitope within the N-terminal region of human CD61, also known as integrin beta 3 (ITGB3). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. CD61 is a 90-110 kDa glycoprotein which binds to CD41 (ITGA2B) to form the GPIIb/IIIa complex, and CD51 (ITGAV) to form the vitronectin receptor. Binding of fibrinogen to the GPIIb/IIIa complex brings about platelet/platelet interaction, leading to rapid platelet aggregation and clotting. The vitronectin receptor is essential for endothelial cell migration, proliferation, and prevention of apoptosis. Elevated expression of the vitronectin receptor is associated with tumour progression and metastases formation on melanoma cells, and is used by human cytomegalovirus (HCMV) as a co-receptor to initiate viral entry and signalling.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD61 (N-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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