|Calculated MW||67569 Da|
|Immunogen||Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18.|
|Shelf Life||12 months from date of despatch.|
|Other Names||Syntaxin-binding protein 1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, rbSec1, Stxbp1, Unc18a|
|Target/Specificity||ABD13289 recognises Munc-18 phosphorylated at serine 515, a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C.Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti MUNC-18 (pSer515) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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