|Application ||WB, IHC-F, IF, E|
|Calculated MW||24008 Da|
|Purification||Purified IgG prepared by Immunoaffinity chromatography|
|Immunogen||Native human cardiac troponin I, purity greater than 98%.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1|
|Target/Specificity||Goat anti Human Troponin I antibody recognizes human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivoandin vitro.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Troponin I (Cardiac) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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