|Application ||WB, E, Func|
|Calculated MW||18045 Da|
|Immunogen||Recombinant human IL-17F|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Interleukin-17F, IL-17F, Cytokine ML-1, IL17F|
|Target/Specificity||ABD13299 is specific for human IL-17F (interleukin-17F), a disulphide-linked homodimer consisting of two 133 amino acid chains, which belongs to the IL-17 gene family and shares the highest sequence homology with IL-17A.IL-17F is expressed by activated CD4+ T-cells and monocytes, and acts as a stimulator of cytokine production, including granulocyte colony-stimulating factor (GM-CSF), IL-6 and IL-8. IL-7F also stimulates the production of IL-2, MCP-1 (monocyte chemotactic protein-1) and TGFB (Transforming growth factor beta) by endothelial cells, and inhibits endothelial cell angiogenesis.ABD13299 has been used in neutralisation assays where 50% inhibition (ND50) of the biological activity of 50ng/ml of human IL-17F was achieved using 0.9-1.2ug/ml of antibody.|
|Preservative & Stabilisers||None present|
|Storage||Store at +4oC or at -20oC if preferred.|
|Precautions||Anti Human Interleukin-17F Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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