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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti Human Notch 2 Antibody    

Anti Human Notch 2 Antibody

Rabbit Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q04721
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 265405 Da
Additional Information
Immunogen Synthetic peptide corresponding to amino acids 2396-2409 of human Notch 2.
Shelf Life 18 months from date of despatch.
Gene ID 4853
Other Names Neurogenic locus notch homolog protein 2, Notch 2, hN2, Notch 2 extracellular truncation, Notch 2 intracellular domain, NOTCH2
Target/Specificity ABD13301 detects Notch 2, an important signalling protein which is critical for embryonic development. Notch 2 is a type 1 transmembrane protein that is activated by Delta1, Jagged1 and Jagged2. Activation results in cleavage and translocation of the Notch intracellular domain (NICD) to the nucleus, where it functions as a transcriptional regulator.Notch 2 activation results in differentiation and proliferation in many cells, in particular in myeloid cell differentiation, functioning in the maturation of CD8 thymocytes and the development of Marginal Zone B cells.Recently Notch 2 mutations have been shown to exist in a minority of patients suffering from Alagille syndrome (AGS), a dominant, multi-system disorder. Notch 2 mutations can also be oncogenic, for example in B-cell chronic lymphocytic leukaemia (B-CLL).
Preservative & Stabilisers 0.1%Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human Notch 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13301
(40 western blots)
Availability: Inquire
Bulk Size
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