|Application ||WB, E|
|Calculated MW||265405 Da|
|Immunogen||Synthetic peptide corresponding to amino acids 2396-2409 of human Notch 2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Neurogenic locus notch homolog protein 2, Notch 2, hN2, Notch 2 extracellular truncation, Notch 2 intracellular domain, NOTCH2|
|Target/Specificity||ABD13301 detects Notch 2, an important signalling protein which is critical for embryonic development. Notch 2 is a type 1 transmembrane protein that is activated by Delta1, Jagged1 and Jagged2. Activation results in cleavage and translocation of the Notch intracellular domain (NICD) to the nucleus, where it functions as a transcriptional regulator.Notch 2 activation results in differentiation and proliferation in many cells, in particular in myeloid cell differentiation, functioning in the maturation of CD8 thymocytes and the development of Marginal Zone B cells.Recently Notch 2 mutations have been shown to exist in a minority of patients suffering from Alagille syndrome (AGS), a dominant, multi-system disorder. Notch 2 mutations can also be oncogenic, for example in B-cell chronic lymphocytic leukaemia (B-CLL).|
|Preservative & Stabilisers||0.1%Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Notch 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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