|Calculated MW||51641 Da|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within parkin, which includes phosphorylated Ser378.|
|Shelf Life||12 months from date of despatch.|
|Other Names||E3 ubiquitin-protein ligase parkin, 6.3.2.-, Parkinson juvenile disease protein 2, Parkinson disease protein 2, PARK2, PRKN|
|Target/Specificity||ABD13303 specifically recognises the 52kDa parkin protein, when phosphorylated at Ser378.Parkin is an E3 ubiquitin ligase highly expressed in the brain, which functions in the ubiquitin-proteasome system, together with the E2 ubiquitin conjugating co-enzyme UbcH7. Mutations in the parkin gene are associated with the hereditary neurodegenerative disorder known as autosomal recessive early onset Parkinson disease 2 (PARK2)/autosomal recessive juvenile Parkinson disease (PDJ), characterized by progressive dopaminergic neural cell death. Studies have identified the presence of at least five phosphorylation sites in parkin including Ser378, shown to be phosphorylated by Casein kinase-1 (CK-1), and suggest that phosphorylation of parkin may act to regulate its ubiquitin ligase activity.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Parkin (pSer378) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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