|Application ||WB, E|
|Calculated MW||69413 Da|
|Immunogen||Peptide sequence C-QDYEEKTKKAER from the internal region of ezrin (NP_003370.2).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ezrin, Cytovillin, Villin-2, p81, EZR, VIL2|
|Target/Specificity||Goat anti Human Ezrin antibody recognizes human ezrin, otherwise known as p81 or villin 2, Ezrin is a 586 amino acid ~80kDa cytoplasmic peripheral membrane protein containing a single FERM domain and member of the ezrin, radixin, moesin (ERM) protein family, which acts as protein-tyrosine kinase substrate.Ezrin is enriched in microvilli and other cell surface structures and plays a key role in cell surface structure adhesion, membrane trafficking, motility and organization (Nget al.2001). Ezrin acts as a linker protein between the plasma membrane and the actin cytoskeleton, and provides anchorage for cell surface molecules such as ICAM and CD44 (Finnertyet al.2004). Studies have implicated ezrin in the metastatic capacity of various types of human tumours including breast, prostate, bone, endometrial and colon cancers (Ohtaniet al.1999,Elzaqheidet al.2008).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Ezrin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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