|Application ||WB, IHC-P, E|
|Calculated MW||46920 Da|
|Immunogen||Synthetic peptide corresponding to amino acid sequence 360-369 of Human E2F-1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Transcription factor E2F1, E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1, Retinoblastoma-binding protein 3, RBBP-3, pRB-binding protein E2F-1, E2F1, RBBP3|
|Target/Specificity||Rabbit anti Human E2F1 antibody recognises human E2F1 a ~47 kDa nuclear transcription protein. E2F1 is a transcription activator that binds DNA cooperatively with the differentiation regulated transcription factor proteins (DP). Together they bind to the promoter region of a number of genes whose products are involved in cell cycle regulation or DNA replication. E2F1 also binds to the retinoblastoma protein (RB1), which functions in the control of cell-cycle progression from G1 to S phase. E2F1 can mediate p53-dependent and independent apoptosis. It is a target of the transforming proteins of small DNA tumour viruses and increased expression of this protein has been reported in a variety of cancers.|
|Preservative & Stabilisers||0.01% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human E2F1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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