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Anti Presenilin-1 Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti Presenilin-1 Antibody  ABD13316
    Western blot analysis of human brain lysate with Rabbit anti Human presenilin-1 at 0.5(A), 1(B) and 2(C) ug/ml
  • IHC-P - Anti Presenilin-1 Antibody  ABD13316
    Formalin fixed, paraffin embedded human brain with Rabbit anti Human presenilin-1 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49768
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 52668 Da
Additional Information
Other Species Rat,M
Immunogen A 23 amino acid peptide from near the carboxy terminus of human presenilin-1.
Shelf Life 18 months from date of despatch.
Gene ID 5663
Other Names Presenilin-1, PS-1, 3.4.23.-, Protein S182, Presenilin-1 NTF subunit, Presenilin-1 CTF subunit, Presenilin-1 CTF12, PS1-CTF12, PSEN1, AD3, PS1, PSNL1
Target/Specificity ABD13316 recognises human Presenilin-1, a 52.7 kDa membrane protein expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. Presenilin-1 was originally identified as a marker of susceptibility for familial early onset Alzheimer’s disease type 3 (AD3). Presenilin-1, along with PEN2, Nicastrin and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. Cleavage of these proteins is a key step in signalling from several cell-surface receptors and is believed to be required for the generation of neurotoxic amyloid peptides that are central in the development of Alzheimer’s disease. Research indicates that at least 6 isoforms of Presenilin-1 exist. ABD13316 is specific for Presenilin-1 and shows no cross reactivity with Presenilin-2.
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Presenilin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13316
(40 western blots)
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