|Application ||WB, IHC-P|
|Calculated MW||52668 Da|
|Immunogen||A 23 amino acid peptide from near the carboxy terminus of human presenilin-1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Presenilin-1, PS-1, 3.4.23.-, Protein S182, Presenilin-1 NTF subunit, Presenilin-1 CTF subunit, Presenilin-1 CTF12, PS1-CTF12, PSEN1, AD3, PS1, PSNL1|
|Target/Specificity||ABD13316 recognises human Presenilin-1, a 52.7 kDa membrane protein expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. Presenilin-1 was originally identified as a marker of susceptibility for familial early onset Alzheimer’s disease type 3 (AD3). Presenilin-1, along with PEN2, Nicastrin and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. Cleavage of these proteins is a key step in signalling from several cell-surface receptors and is believed to be required for the generation of neurotoxic amyloid peptides that are central in the development of Alzheimer’s disease. Research indicates that at least 6 isoforms of Presenilin-1 exist. ABD13316 is specific for Presenilin-1 and shows no cross reactivity with Presenilin-2.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Presenilin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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