|Application ||WB, IP|
|Calculated MW||170679 Da|
|Immunogen||Synthetic peptide corresponding to an epitope within amino acid residues 1400-1435 of human TopBP1 (NP_008958.1).|
|Shelf Life||12 months from date of despatch.|
|Other Names||DNA topoisomerase 2-binding protein 1, DNA topoisomerase II-beta-binding protein 1, TopBP1, DNA topoisomerase II-binding protein 1, TOPBP1, KIAA0259|
|Target/Specificity||This product specifically recognizes human TopBP1 (DNA Topoisomerase II Binding Protein I). a phosphoprotein upregulated during the S phase of the cell cycle, which shares sequence homology with Dpb11 (S. cerevisiae), Rad4 (S. pombe), Mus101 (D. melanogaster) and Cut5 (Xenopus).Studies indicate a role for TopBP1 in DNA replication through interaction with DNA polymerase E, in S phase DNA checkpoint control, and in DNA repair response to ionizing radiation damage. TopBP1 co-localizes with BRCA1 and is an important factor in minimising stalled replication forks and double-strand breaks (DSB), thereby maintaining genomic integrity.|
|Preservative & Stabilisers||0.1% Sodium Azide (NaN3)|
|Storage||Store at +4℃.DO NOT FREEZE.|
|Precautions||Anti Human TOPBP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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