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Anti Human CD279 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti Human CD279 (C-Terminal) Antibody  ABD13330
    Western blot analysis of whole cell lysate from THP-1 promocytic leukemia cells probed with Rabbit anti Human CD279
  • IHC - Anti Human CD279 (C-Terminal) Antibody  ABD13330
    Immunohistochemical staining of human brain with Rabbit anti Human CD279
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q15116
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 31647 Da
Additional Information
Other Species M
Immunogen A peptide corresponding to a 16 amino acid sequence from near the carboxy terminus of Human CD279.
Shelf Life 18 months from date of despatch.
Gene ID 5133
Other Names Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1
Target/Specificity Rabbit anti Human CD279 antibody detects CD279, a co-stimulatory molecule also known as programmed cell death-1 (PD-1). CD279 is a single-pass type 1 membrane protein belonging to the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands; CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation.Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion (Freemanet al.2006).
Preservative & Stabilisers 0.02% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human CD279 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13330
(40 western blots)
Availability: Inquire
Bulk Size
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