|Application ||WB, IHC-P|
|Calculated MW||59123 Da|
|Immunogen||A peptide corresponding to a 18 amino acid sequence from near the centre of Human MAPKAP1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Target of rapamycin complex 2 subunit MAPKAP1, TORC2 subunit MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, Stress-activated map kinase-interacting protein 1, SAPK-interacting protein 1, mSIN1, MAPKAP1, MIP1, SIN1|
|Target/Specificity||Rabbit anti MAPKAP1 antibody recognizes the human Mitogen activated protein kinase associated protein 1 (MAPKAP1).MAPKAP1 forms and essential component of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation. It is believed to modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation and also inhibits HRAS and KRAS signaling. MAPKAP1 enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.MAPKAP1 is a ubiquitously expressed protein with highest levels being detected in the heart and skeletal muscle. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.|
|Preservative & Stabilisers||0.02% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti MAPKAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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