|Application ||IHC-P, E|
|Calculated MW||180429 Da|
|Immunogen||Synthetic peptide sequence (C)MTSVATAKGYTSDL corresponding to an internal region of human LRP6.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Low-density lipoprotein receptor-related protein 6, LRP-6, LRP6|
|Target/Specificity||Goat anti Human LRP6 antibody recognizes human Low-density lipoprotein receptor-related protein 6 (LRP-6). LRP6 is a widely expressed 1594 amino acid ~:200 kDa single pass type I endoplasmic reticular transmembrane glycoprotein. LRP6 is released from the endoplasmic reticulum of palmitoylation.LRP6 is involved with Wnt Frizzled and LRP5 in the formation of signalosomes, inducing beta catenin signaling (Bilicet al.2007). Mutations in the LRP6 gene can lead to development of Coronary artery disease, autosomal dominant, 2 (ADCAD2) a disease characterised by reduced or absent blood flow in one or more arteries supplying the heart which can in some cases lead to acute myocardial infarction (Maniet al.2007).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human LRP6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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