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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti Bovine Carboxypeptidase A1 Antibody    

Anti Bovine Carboxypeptidase A1 Antibody

Rabbit Anti-Bovine Polyclonal Antibody

     
  • IHC-P - Anti Bovine Carboxypeptidase A1 Antibody  ABD13360
    Staining of formalin fixed, paraffin embedded human pancreas with Rabbit anti Bovine carboxypeptidase 1
  • IHC - Anti Bovine Carboxypeptidase A1 Antibody  ABD13360
    Immunoperoxidase staining of human pancreas with Rabbit anti Bovine carboxypeptidase A1 antibody and HISTAR detection kit. Low power
  • IHC - Anti Bovine Carboxypeptidase A1 Antibody  ABD13360
    Immunoperoxidase staining of human pancreas with Rabbit anti Bovine carboxypeptidase A1 antibody and HISTAR detection kit. Med power
  • IHC - Anti Bovine Carboxypeptidase A1 Antibody  ABD13360
    Immunoperoxidase staining of human pancreas with Rabbit anti Bovine carboxypeptidase A1 antibody and HISTAR detection kit. High power
  • WB - Anti Bovine Carboxypeptidase A1 Antibody  ABD13360
    Published customer image:Rabbit anti Bovine Carboxypeptidase A1 antibody used for the evaluation of carboxypepridase and pro-carboxypeptidase in mive tissue lysates by western blotting.Image caption:STC2 over-expression reduces severity of acinar cell damage during cerulein-induced pancreatic injury. (A) Analysis of serum amylase levels four hours into CIP treatment show that serum amylase levels rise approximately 3 fold in WT mice when compared to saline (•) whereas the increase in STC2Tg mice is significantly lower at 2-fold (¦; * p < 0.01). (B) Tissue edema analysis revealed significant increases for both WT and STC2Tg tissue 4 hours into CIP (black bars) when compared to saline controls (white bars; n = 4 animals). No difference between genotypes was observed. (C) Representative Western blot for procarboxypeptidase (47 kDa) and carboxypeptidase (CPA; 33 kDa) or trypsinogen four hours after initial saline (Sal.) or cerulein injections showed decreased accumulation of activate CPA in STC2Tg mice four hours into CIP. Trypsinogen levels do not differ between genotypes. (D) Quantification by densitometry comparing the ratio of cleaved (active; 33 kDa) to total CPA revealed a significant increase in WT tissue and, to a significantly lower extent, in STC2Tg tissue (n = 4 animals, letters represent statistically different values; p < 0.05). IF analysis for β-catenin (E-H) or Cx32 (I-L) in wild type or STC2Tg mice four hours after initial injection of saline (E, G, I, K) or cerulein (F, H, J, L) showing decreased accumulation only in WT tissue during CIP. (M) Representative Western blot analysis on pancreatic protein extracts 4 hours after initial saline or cerulein injection confirm decreased β-catenin and Cx32 accumulation only in WT-CIP treated tissue (n = 4).From: Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL. Stanniocalcin 2 altersPERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.BMC Cell Biol. 2011 May 5;12:17.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P00730
Reactivity Bovine
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 47082 Da
Additional Information
Other Species H
Immunogen Carboxypeptidase A1 from bovine pancreas.
Shelf Life 18 months from date of despatch.
Gene ID 286762
Other Names Carboxypeptidase A1, 3.4.17.1, CPA1, CPA
Target/Specificity Rabbit anti Bovine Carboxypeptidase A1 antibody recognizes bovine Carboxypeptidase A1, a 309 amino acid monomeric pancreatic extopeptidase derived by cleavage of the propeptide. Carboxypeptidase A1 belongs to the peptidase M14 family (UniProt: P00370).
Preservative & Stabilisers 0.01% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Bovine Carboxypeptidase A1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13360
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