|Application ||WB, E|
|Calculated MW||77329 Da|
|Immunogen||Synthetic peptide sequence C-NFESDKLKAVKGFR from the internal region (near the C- Terminal) of TGM2 (NP_004604.2).|
|Shelf Life||18 months from date of despatch.|
|Other Names||Protein-glutamine gamma-glutamyltransferase 2, 188.8.131.52, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2|
|Target/Specificity||Goat anti Human transglutaminase 2 antibody recognizes human Protein-glutamine gamma-glutamyltransferase 2, also known as Transglutaminase 2 (TGM2), or tissue Transglutaminase (tTG). TGM2 is a 687 amino acid member of the Transglutaminase family. It is a ubiquitously expressed calcium-dependent enzyme, with GTPase activity, which catalyzes protein cross-linking and the conjugation of polyamines to proteins.TGM2 has been implicated in several processes, including apoptosis (Hseihet al.2013), the regulation of cytoskeletal structure, cell-matrix adhesion, cell migration, and wound healing (Fesus and Piacentini 2002). Antibodies against tTG are apparent in a high majority of patients with the autoimmune condition known as celiac disease, resulting in sensitivity to gluten (Geldermanet al.2014). Three isoforms of TGM2 generated by alternative splicing exist. Goat anti Human transglutaminase 2 antibody is generated against a peptide spanning amino acid residues 667-680 of isoform 1. It does not recognize the other isoforms having carboxy-terminal deletions.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human Transglutaminase 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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